Caspase-dependent cleavage of 170-kDa P-glycoprotein during apoptosis of human T-lymphoblastoid CEM cells.

@article{Mantovani2006CaspasedependentCO,
  title={Caspase-dependent cleavage of 170-kDa P-glycoprotein during apoptosis of human T-lymphoblastoid CEM cells.},
  author={Irina Mantovani and Alessandra Cappellini and Pier Luigi Tazzari and Veronica Papa and Lucio Cocco and Alberto Maria Martelli},
  journal={Journal of cellular physiology},
  year={2006},
  volume={207 3},
  pages={
          836-44
        }
}
Multidrug resistance (MDR) mediated by the drug efflux protein, 170-kDa P-glycoprotein (P-gp), is one mechanism that tumor cells use to escape cell death induced by chemotherapeutic drugs. Moreover, evidence suggests that cell lines expressing high levels of 170-kDa P-gp are less sensitive to caspase-mediated apoptosis induced by a wide range of death stimuli, including Fas ligand, tumor necrosis factor, and ultraviolet irradiation. However, the fate of 170-kDa P-gp during apoptosis is unknown… CONTINUE READING

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