Caspase-dependent apoptosis during infection with Cryptosporidium parvum.

@article{Ojcius1999CaspasedependentAD,
  title={Caspase-dependent apoptosis during infection with Cryptosporidium parvum.},
  author={David M. Ojcius and J L Perfettini and Ana Bonnin and Fabrice Laurent},
  journal={Microbes and infection},
  year={1999},
  volume={1 14},
  pages={1163-8}
}
The protozoan parasite Cryptosporidium parvum causes persistent diarrhea and malnutrition in children and the diarrhea-wasting syndrome in AIDS. No therapy exists for eliminating the parasite in the absence of a healthy immune response. Although it had been reported that infection of intestinal cell lines with C. parvum leads to host cell death, the mechanisms of cytolysis have not been characterized. We show here that infection with C. parvum leads to typical apoptotic nuclear condensation and… CONTINUE READING