Caspase-dependent activation of calpain during drug-induced apoptosis.

@article{Wood1999CaspasedependentAO,
  title={Caspase-dependent activation of calpain during drug-induced apoptosis.},
  author={David Eldon Wood and Elizabeth Wormwood Newcomb},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 12},
  pages={
          8309-15
        }
}
We have previously demonstrated that calpain is responsible for the cleavage of Bax, a proapoptotic protein, during drug-induced apoptosis of HL-60 cells (Wood, D. E., Thomas, A., Devi, L. A., Berman, Y., Beavis, R. C., Reed, J. C., and Newcomb, E. W. (1998) Oncogene 17, 1069-1078). Here we show the sequential activation of caspases and calpain during drug-induced apoptosis of HL-60 cells. Time course experiments using the topoisomerase I inhibitor 9-amino-20(S)-camptothecin revealed that… CONTINUE READING
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