Caspase cascades in human immunodeficiency virus-associated neurodegeneration.

  title={Caspase cascades in human immunodeficiency virus-associated neurodegeneration.},
  author={Gwenn A Garden and Samantha L. Budd and Elena Tsai and Lisa Hanson and Marcus Kaul and Danielle M D'Emilia and Robert Max Friedlander and Junying Yuan and Eliezer Masliah and Stuart Lipton},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={22 10},
Many patients infected with human immunodeficiency virus-1 (HIV-1) develop a syndrome of neurologic deterioration known as HIV-associated dementia (HAD). Neurons are not productively infected by HIV-1; thus, the mechanism of HIV-induced neuronal injury remains incompletely understood. Several investigators have observed evidence of neuronal injury, including dendritic degeneration, and apoptosis in CNS tissue from patients with HAD. Caspase enzymes, proteases associated with the process of… CONTINUE READING


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