Caspase-activation pathways in apoptosis and immunity.

  title={Caspase-activation pathways in apoptosis and immunity.},
  author={Emma M. Creagh and Helen Conroy and Seamus J. Martin},
  journal={Immunological reviews},
Members of the caspase family of cysteine proteases have been firmly established to play key roles in signal transduction cascades that culminate in apoptosis (programmed cell death). Caspases are normally expressed as inactive precursor enzymes (zymogens) that become activated during apoptosis and proceed to dismantle the cell from within. To date, three major apoptosis-associated pathways to caspase activation have been elucidated. Certain caspases, such as caspase-1, also occupy important… CONTINUE READING

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