Caspase activation is an early event in anthracycline-induced apoptosis and allows detection of apoptotic cells before they are ingested by phagocytes.

@article{Durrieu1998CaspaseAI,
  title={Caspase activation is an early event in anthracycline-induced apoptosis and allows detection of apoptotic cells before they are ingested by phagocytes.},
  author={Françoise Durrieu and Françis Belloc and Laurent Lacoste and Patrice Dumain and Julien Chabrol and Jeanne Dachary-Prigent and Hamid Morjani and M R Boisseau and Josy J Reiffers and P G Bernard and Francis Lacombe},
  journal={Experimental cell research},
  year={1998},
  volume={240 2},
  pages={165-75}
}
An increasing number of methods are being described to detect apoptotic cells. However, attempts to detect apoptotic cells in clinical samples are rarely successful. A hypothesis is that apoptotic cells are cleared from the circulation by phagocytosis before they become detectable by conventional morphological or cytometric methods. Using LR73 adhering cells as phagocytes in a model of in vitro phagocytosis, we found that phagocytosis of daunorubicin (DNR)-treated U937, HL60, or K562 leukemia… CONTINUE READING

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