Caspase activation by adenovirus e4orf4 protein is cell line specific and Is mediated by the death receptor pathway.

@article{Livne2001CaspaseAB,
  title={Caspase activation by adenovirus e4orf4 protein is cell line specific and Is mediated by the death receptor pathway.},
  author={Alexander Livne and Ronit Shtrichman and Tamar Kleinberger},
  journal={Journal of virology},
  year={2001},
  volume={75 2},
  pages={
          789-98
        }
}
Adenovirus E4orf4 protein has been shown to induce transformed cell-specific, protein phosphatase 2A-dependent, and p53-independent apoptosis. It has been further reported that the E4orf4 apoptotic pathway is caspase-independent in CHO cells. Here, we show that E4orf4 induces caspase activation in the human cell lines H1299 and 293T. Caspase activation is required for apoptosis in 293T cells, but not in H1299 cells. Dominant negative mutants of caspase-8 and the death receptor adapter protein… CONTINUE READING
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