Caspase activation, inhibition, and reactivation: a mechanistic view.

@article{Shi2004CaspaseAI,
  title={Caspase activation, inhibition, and reactivation: a mechanistic view.},
  author={Yigong Shi},
  journal={Protein science : a publication of the Protein Society},
  year={2004},
  volume={13 8},
  pages={1979-87}
}
  • Yigong Shi
  • Published 2004 in
    Protein science : a publication of the Protein…
Caspases, a unique family of cysteine proteases, execute programmed cell death (apoptosis). Caspases exist as inactive zymogens in cells and undergo a cascade of catalytic activation at the onset of apoptosis. The activated caspases are subject to inhibition by the inhibitor-of-apoptosis (IAP) family of proteins. This inhibition can be effectively removed by diverse proteins that share an IAP-binding tetrapeptide motif. Recent structural and biochemical studies have revealed the underlying… CONTINUE READING

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