Caspase-Mediated Truncation of Tau Potentiates Aggregation

  title={Caspase-Mediated Truncation of Tau Potentiates Aggregation},
  author={Sangmook Lee and Thomas B. Shea},
  booktitle={International journal of Alzheimer's disease},
Caspase-mediated truncation of tau is associated with aggregation. We examined the impact of manipulation of caspase activity on intracellular aggregation of a mutant form of tau (3PO) that forms spontaneous aggregates. Treatment with the caspase inhibitor Z-VAD-fmk reduced both N and C-terminal tau truncation but did not significantly reduce aggregation. Treatment with staurosporine, which activated caspases, increased C-terminal but not N-terminal truncation and enhanced aggregation. These… CONTINUE READING


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