Caspase Inhibitors Protect Neurons by Enabling Selective Necroptosis of Inflamed Microglia*

@inproceedings{Fricker2013CaspaseIP,
  title={Caspase Inhibitors Protect Neurons by Enabling Selective Necroptosis of Inflamed Microglia*},
  author={Michael Fricker and Anna Vilalta and Aviva M Tolkovsky and Guy C Brown},
  booktitle={The Journal of biological chemistry},
  year={2013}
}
Microglia are resident brain macrophages, which can cause neuronal loss when activated in infectious, ischemic, traumatic, and neurodegenerative diseases. Caspase-8 has both prodeath and prosurvival roles, mediating apoptosis and/or preventing RIPK1-mediated necroptosis depending on cell type and stimulus. We found that inflammatory stimuli (LPS, lipoteichoic acid, or TNF-α) caused an increase in caspase-8 IETDase activity in primary rat microglia without inducing apoptosis. Inhibition of… CONTINUE READING
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