Caspase-9 and APAF-1 form an active holoenzyme.

  title={Caspase-9 and APAF-1 form an active holoenzyme.},
  author={J. Rodriguez and Yuri A. Lazebnik},
  journal={Genes & development},
  volume={13 24},
Autocatalytic activation of initiator caspases is the link between pro-apoptotic signals and the destruction machinery of apoptosis. Activation of caspase-9, which mediates oncogene and drug-induced apoptosis, requires binding to the protein APAF-1. We found that the proteolytic activity of caspase-9 in a complex with APAF-1 is several orders of magnitude higher than that of the free enzyme. Thus, this complex functions as a holoenzyme in which caspase-9 is the catalytic subunit and APAF-1 its… CONTINUE READING
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