Caspase-8 regulation of TRAIL-mediated cell death.

  title={Caspase-8 regulation of TRAIL-mediated cell death.},
  author={Roslyn N. Crowder and Wafik S El-Deiry},
  journal={Experimental oncology},
  volume={34 3},
Research on TNF-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors has advanced tremendously over the past 17 years. Initial observations of TRAIL and TRAIL receptor-mediated tumor cell toxicity led to enthusiasm of exploiting this selective, malignant cell killing for cancer therapy. Further examination revealed aberrant TRAIL signaling in some… CONTINUE READING