Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis.

  title={Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis.},
  author={Simone Barbero and Ainhoa Mielgo and Vicente E. Torres and Tal Teitz and David J. Shields and David P Mikolon and Matthew S Bogyo and Daniela Baril{\`a} and Jill M. Lahti and David D. Schlaepfer and Dwayne G. Stupack},
  journal={Cancer research},
  volume={69 9},
Caspase-8 is a proapoptotic protease that suppresses neuroblastoma metastasis by inducing programmed cell death. Paradoxically, caspase-8 can also promote cell migration among nonapoptotic cells; here, we show that caspase-8 can promote metastasis when apoptosis is compromised. Migration is enhanced by caspase-8 recruitment to the cellular migration machinery following integrin ligation. Caspase-8 catalytic activity is not required for caspase-8-enhanced cell migration; rather, caspase-8… CONTINUE READING
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