Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.

  title={Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.},
  author={Dan Weng and Robyn Lynn Marty-Roix and Sandhya Ganesan and Megan M Proulx and Gregory I Vladimer and William J. Kaiser and Edward S. Mocarski and Kimberly Lea Pouliot and Francis Ka-Ming Chan and Michelle A Kelliher and Phillip A Harris and John Bertin and Peter J Gough and Dmitry M. Shayakhmetov and Jon D Goguen and Katherine A. Fitzgerald and Neal Silverman and Egil Lien},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 20},
A number of pathogens cause host cell death upon infection, and Yersinia pestis, infamous for its role in large pandemics such as the "Black Death" in medieval Europe, induces considerable cytotoxicity. The rapid killing of macrophages induced by Y. pestis, dependent upon type III secretion system effector Yersinia outer protein J (YopJ), is minimally affected by the absence of caspase-1, caspase-11, Fas ligand, and TNF. Caspase-8 is known to mediate apoptotic death in response to infection… CONTINUE READING


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