Caspase-8 activation precedes alterations of mitochondrial membrane potential during monocyte apoptosis induced by phagocytosis and killing of Staphylococcus aureus.

Abstract

Human peripheral blood monocytes become apoptotic following phagocytosis and killing of Staphylococcus aureus. Although this type of monocyte apoptosis is known to be initiated by Fas-Fas ligand (FasL) interactions, the downstream signaling pathway has not been determined. In this work the involvement of mitochondria and the kinetics of caspase-8 and… (More)

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@article{Wglarczyk2004Caspase8AP, title={Caspase-8 activation precedes alterations of mitochondrial membrane potential during monocyte apoptosis induced by phagocytosis and killing of Staphylococcus aureus.}, author={Kazimierz Węglarczyk and Jarosław Baran and Marek Zembala and Juliusz R Pryjma}, journal={Infection and immunity}, year={2004}, volume={72 5}, pages={2590-7} }