Caspase-8 activation and oxidative stress are involved in the cytotoxic effect of beta-amyloid on rat brain microvascular endothelial cells.

@article{Folin2006Caspase8AA,
  title={Caspase-8 activation and oxidative stress are involved in the cytotoxic effect of beta-amyloid on rat brain microvascular endothelial cells.},
  author={Marcella Folin and Silvia Baiguera and Lara Fioravanzo and Maria Teresa Conconi and Claudio Grandi and Gastone Giovanni Nussdorfer and Pier Paolo Parnigotto},
  journal={International journal of molecular medicine},
  year={2006},
  volume={17 3},
  pages={431-5}
}
Several studies have demonstrated that cerebrovascular dysfunction and damage play a significant role in the pathogenesis of Alzheimer disease (AD). In fact, beta-amyloid peptides (Abetas), the major component of the senile plaques and cerebrovascular amyloid deposits in AD, were shown to be cytotoxic to endothelial cells. We have recently observed that Abetas exert a toxic effect on neuromicrovascular endothelial cells (NECs) in a time- and concentration-dependent manner, apoptosis playing a… CONTINUE READING

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