Caspase-8 Regulation by Direct Interaction with TRAF6 in T Cell Receptor-Induced NF-κB Activation

@article{Bidre2006Caspase8RB,
  title={Caspase-8 Regulation by Direct Interaction with TRAF6 in T Cell Receptor-Induced NF-κB Activation},
  author={Nicolas Bid{\`e}re and Andrew L Snow and Keiko Sakai and Lixin Zheng and Michael J Lenardo},
  journal={Current Biology},
  year={2006},
  volume={16},
  pages={1666-1671}
}
Triggering of lymphocyte antigen receptors is the critical first step in the adaptive immune response against pathogens. T cell receptor (TCR) ligation assembles a large membrane signalosome, culminating in NF-kappaB activation [1,2]. Recently, caspase-8 was found to play a surprisingly prominent role in lymphocyte activation in addition to its well-known role in apoptosis [3]. Caspase-8 is activated after TCR stimulation and nucleates a complex with B cell lymphoma 10 (BCL10), paracaspase… CONTINUE READING
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