Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease.

@article{LeBlanc1999Caspase6RI,
  title={Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease.},
  author={Andr{\'e}a C LeBlanc and Hongtu Liu and Cynthia Gates Goodyer and Catherine Racicot Bergeron and James M. Hammond},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 33},
  pages={23426-36}
}
Neuronal cell death, neurofibrillary tangles, and amyloid beta peptide (Abeta) deposition depict Alzheimer's disease (AD) pathology, but neuronal loss correlates best with dementia. We have shown that increased production of Abeta is a consequence of neuronal apoptosis, suggesting that apoptosis activates proteases involved in amyloid precursor protein (APP) processing. Here, we investigate key effectors of cell death, caspases, in human neuronal apoptosis and APP processing. We find that… CONTINUE READING
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