Caspase-3 is required in the apoptotic disintegration of the nuclear matrix.

@article{Kivinen2005Caspase3IR,
  title={Caspase-3 is required in the apoptotic disintegration of the nuclear matrix.},
  author={Katri Kivinen and Markku Kallajoki and Pekka Taimen},
  journal={Experimental cell research},
  year={2005},
  volume={311 1},
  pages={62-73}
}
Apoptotic breakdown of cellular structures is largely mediated by caspases. One target of degradation is a proteinaceous framework of the nucleus termed the nuclear matrix. We compared the apoptotic changes of the nuclear matrix in staurosporine-treated caspase-3-deficient MCF-7 cells transfected with intact CASP-3 gene (MCF-7c3) or an empty vector (MCF-7v) as a control. Nuclear Mitotic Apparatus protein (NuMA), lamin A/C and lamin B were used as markers for internal nuclear matrix and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

Lamin B1 loss is a senescence-associated biomarker

Molecular biology of the cell • 2012
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…