Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis.

@article{Jnicke1998Caspase3IR,
  title={Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis.},
  author={Reiner U. J{\"a}nicke and Patrick Wei Pern Ng and M L Sprengart and A. G. Porter},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 25},
  pages={15540-5}
}
Although the commonly activated death protease caspase-3 appears not to be essential for apoptosis during development except in the brain, it was not shown whether substrates known to be cleaved by caspase-3 are still proteolyzed in its absence. We have addressed this question with MCF-7 breast carcinoma cells that we recently showed lack caspase-3 owing to the functional deletion of the CASP-3 gene. Tumor necrosis factor- or staurosporine-induced apoptosis of caspase-3-deficient MCF-7 cells… CONTINUE READING

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