Caspase-3 is essential for procaspase-9 processing and cisplatin-induced apoptosis of MCF-7 breast cancer cells.

@article{Blanc2000Caspase3IE,
  title={Caspase-3 is essential for procaspase-9 processing and cisplatin-induced apoptosis of MCF-7 breast cancer cells.},
  author={C{\'e}line Blanc and Quinn L. Deveraux and Stanislaw Krajewski and Reiner U. J{\"a}nicke and A. G. Porter and John C. Reed and Ricky Jaggi and Antonio Marti},
  journal={Cancer research},
  year={2000},
  volume={60 16},
  pages={
          4386-90
        }
}
In this study, we sought to investigate in more detail the role of caspase-3 in apoptotic processes in cultured cells and in cell-free extracts of breast cancer cells. We present evidence that apoptosis of caspase-3-deficient MCF-7 breast cancer cells is defective in response to cisplatin treatment, as determined by chromatin condensation, nuclear fragmentation, DNA fragmentation, and release of cytochrome c from the mitochondria. Reconstitution of MCF-7 cells by stable transfection of CASP-3… CONTINUE READING

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