Caspase-3 is actively involved in okadaic acid-induced lens epithelial cell apoptosis.

@article{Li2001Caspase3IA,
  title={Caspase-3 is actively involved in okadaic acid-induced lens epithelial cell apoptosis.},
  author={Dayu Li and Hua Xiang and Y. W. Mao and Jinzhao Wang and Uwe Fass and Xi Yi Zhang and Caimin Xu},
  journal={Experimental cell research},
  year={2001},
  volume={266 2},
  pages={279-91}
}
Phosphorylation and dephosphorylation are important cellular events regulating major metabolic activities such as signal transduction, gene expression, cell cycle progression, and apoptosis. It is well documented that okadaic acid, a potent inhibitor of protein phosphatase-1 (PP-1) and -2A (PP-2A), can induce apoptosis in a variety of cell lines. Our recent studies have revealed that in the immortal rabbit lens epithelial cell line, N/N1003A, inhibition of PP-1, but not PP-2A, leads to rapid… CONTINUE READING

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