Caspase-3 is Involved in IFN-γ- and TNF-α-Mediated MIN6 Cells Apoptosis via NF-κB/Bcl-2 Pathway

@article{Cao2013Caspase3II,
  title={Caspase-3 is Involved in IFN-γ- and TNF-α-Mediated MIN6 Cells Apoptosis via NF-κB/Bcl-2 Pathway},
  author={Zhao-hui Cao and Wei-dong Yin and Quan-you Zheng and Shao-long Feng and Gui-lian Xu and Ke-Qin Zhang},
  journal={Cell Biochemistry and Biophysics},
  year={2013},
  volume={67},
  pages={1239-1248}
}
TNF-α and IFN-γ are the major pro-inflammatory cytokines in the β-cell destruction. However, the underlying mechanism remains unclear. The present study used a murine insulinoma cell line MIN6 for further investigation of the effect of Caspase-3 on the cytokines-induced pancreatic β-cell apoptosis and analyzed the mechanisms involved in the activation of Caspase-3. It was showed that the combination of IFN-γ and TNF-α significantly reduced the viability of MIN6 cells and the observed cells… CONTINUE READING

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