Caspase-3-dependent apoptosis of citreamicin ε-induced HeLa cells is associated with reactive oxygen species generation.

@article{Liu2013Caspase3dependentAO,
  title={Caspase-3-dependent apoptosis of citreamicin ε-induced HeLa cells is associated with reactive oxygen species generation.},
  author={Ling-Li Liu and Li-sheng He and Ying Xu and Zhuang Han and Yong-Xin Li and Jia-liang Zhong and Xian-Rong Guo and Xi-Xiang Zhang and Kam Ming Ko and Pei-Yuan Qian},
  journal={Chemical research in toxicology},
  year={2013},
  volume={26 7},
  pages={1055-63}
}
Citreamicins, members of the polycyclic xanthone family, are promising antitumor agents that are produced by Streptomyces species. Two diastereomers, citreamicin ε A (1) and B (2), were isolated from a marine-derived Streptomyces species. The relative configurations of these two diastereomers were determined using NMR spectroscopy and successful crystallization of citreamicin ε A (1). Both diastereomers showed potent cytotoxic activity against HeLa (cervical cancer) and HepG2 (hepatic carcinoma… CONTINUE READING