Caspase-3 cleaves the expanded androgen receptor protein of spinal and bulbar muscular atrophy in a polyglutamine repeat length-dependent manner.

@article{Kobayashi1998Caspase3CT,
  title={Caspase-3 cleaves the expanded androgen receptor protein of spinal and bulbar muscular atrophy in a polyglutamine repeat length-dependent manner.},
  author={Yoshinori Kobayashi and Shiro Miwa and Diane E. Merry and Akihiro Kume and Lin Mei and Manabu Doyu and Gen Sobue},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={252 1},
  pages={145-50}
}
Spinal and bulbar muscular atrophy (SBMA) is one of a group of human inherited neurodegenerative diseases caused by polyglutamine expansion. There is increasing evidence that generation of truncated proteins containing an expanded polyglutamine tract may be an important step in the pathogenesis of these disorders. We have previously demonstrated that the… CONTINUE READING