Caspase-3 and caspase-9 mediate developmental apoptosis in the mouse olfactory system.

@article{Cowan2004Caspase3AC,
  title={Caspase-3 and caspase-9 mediate developmental apoptosis in the mouse olfactory system.},
  author={Catherine M. Cowan and A. Jane Roskams},
  journal={The Journal of comparative neurology},
  year={2004},
  volume={474 1},
  pages={136-48}
}
Neuronal apoptosis is a key component in the sculpting of tissues during embryonic and postnatal development and is driven largely by the action of caspases. In the mouse olfactory system, caspase-3 and -9 are expressed in olfactory receptor neurons (ORNs) of adult mice, and their selective retrograde activation drives ORN apoptosis following ablation of their target, the olfactory bulb (OB). Here, we show that both of these caspases are expressed at the earliest stages of ORN embryonic… CONTINUE READING