Caspase-3 and -6 expression and activation are targeted by hormone action in the rat ventral prostate during the apoptotic cell death process.

@article{Omezzine2003Caspase3A,
  title={Caspase-3 and -6 expression and activation are targeted by hormone action in the rat ventral prostate during the apoptotic cell death process.},
  author={Asma Omezzine and Claire Mauduit and Eric Tabone and Naoufel Nabli and Ali Bouslama and Mohamed Benahmed},
  journal={Biology of reproduction},
  year={2003},
  volume={69 3},
  pages={752-60}
}
Although the apoptotic cell death process in the prostate is known to be under the control of androgens, the key components targeted by the hormones remain to be investigated. In the present study, we report that the expression and the activation of the effector caspases-3 and -6 are under the control of testosterone in the adult rat ventral prostate. By using a model of adult castrated rats supplemented (or not) with androgens, we observed an increase in caspase-3 (3-fold) and -6 (4-fold) mRNA… CONTINUE READING

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