Caspase-3 activity is present in cerebrospinal fluid from patients with traumatic brain injury

@article{Hrter2001Caspase3AI,
  title={Caspase-3 activity is present in cerebrospinal fluid from patients with traumatic brain injury},
  author={Luc H{\"a}rter and Mitchell Keel and Hannes Hentze and Marcel Leist and Wolfgang Ertel},
  journal={Journal of Neuroimmunology},
  year={2001},
  volume={121},
  pages={76-78}
}
Loss of neurons after traumatic brain injury (TBI) might involve dysregulated apoptosis. Activation of caspase-3 is one hallmark of apoptosis. Therefore, caspase-3 activity (cleavage of DEVD-afc) was measured in cerebrospinal fluid (CSF) samples (n=113) from 27 patients with TBI at day 1 to 14 after trauma. Caspase-3 activity was detected in 31 (27.4%) CSF samples with highest values (> 5.5 microM/min) seen at day 2-5 after trauma. No caspase-3 activity was found in serum from patients or CSF… CONTINUE READING
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