Caspase-3 activation is required for Leydig cell apoptosis induced by ethane dimethanesulfonate.

@article{Kim2000Caspase3AI,
  title={Caspase-3 activation is required for Leydig cell apoptosis induced by ethane dimethanesulfonate.},
  author={Jung-whan Kim and Lixia Luo and Barry R. Zirkin},
  journal={Endocrinology},
  year={2000},
  volume={141 5},
  pages={1846-53}
}
Previous studies have shown that ethane dimethanesulfonate (EDS) causes the apoptotic death of Leydig cells. The molecular mechanism by which EDS elicits its effect remains uncertain. The present study tested the hypothesis that caspase-3 is involved in the EDS-induced death of rat Leydig cells. Leydig cells were isolated from adult Sprague Dawley at 3, 6, 12, or 24 h after the rats received an EDS injection. Low mol wt DNA fragments that are characteristic of apoptosis were evident by 12 h… CONTINUE READING