Caspase-2 is required for cell death induced by cytoskeletal disruption

@article{Ho2008Caspase2IR,
  title={Caspase-2 is required for cell death induced by cytoskeletal disruption},
  author={Lien Ha Ho and Stuart H. Read and Loretta E Dorstyn and Lidia Lambrusco and Shailendra Kumar},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={3393-3404}
}
Caspase-2 is one of the most conserved caspases, yet its biological function remains a matter of controversy. In the present article we analysed mouse embryonic fibroblasts (MEFs) from caspase-2 knockout mice for their sensitivity to various apoptosis inducing agents. We found that cell death induced by drugs that disrupt cytoskeleton is significantly inhibited in Casp2−/− MEFs. These drugs included zoledronic acid, vincristine, cytochalasin D and paclitaxel. We demonstrate that MEFs lacking… CONTINUE READING
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Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is mediated by Apaf1 and caspase-9

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