Caspase-2 is required for cell death induced by cytoskeletal disruption

  title={Caspase-2 is required for cell death induced by cytoskeletal disruption},
  author={Lien Ha Ho and Stuart H. Read and Loretta E Dorstyn and Lidia Lambrusco and Shailendra Kumar},
Caspase-2 is one of the most conserved caspases, yet its biological function remains a matter of controversy. In the present article we analysed mouse embryonic fibroblasts (MEFs) from caspase-2 knockout mice for their sensitivity to various apoptosis inducing agents. We found that cell death induced by drugs that disrupt cytoskeleton is significantly inhibited in Casp2−/− MEFs. These drugs included zoledronic acid, vincristine, cytochalasin D and paclitaxel. We demonstrate that MEFs lacking… CONTINUE READING
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Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is mediated by Apaf1 and caspase-9

  • LA O’Reilly, P Ekert, N Harvey, V Marsden, L Cullen, DL Vaux
  • Cell Death Differ
  • 2002
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