Caspase-2 involvement during ionizing radiation-induced oocyte death in the mouse ovary

@article{Hanoux2007Caspase2ID,
  title={Caspase-2 involvement during ionizing radiation-induced oocyte death in the mouse ovary},
  author={Vincent Hanoux and Catherine Pairault and Mariana V. Bakalska and Ren{\'e} Habert and Gabriel Livera},
  journal={Cell Death and Differentiation},
  year={2007},
  volume={14},
  pages={671-681}
}
In mammals, the pool of primordial follicles at birth is determinant for female fertility. Exposure to IR during oogonia proliferation and the diplotene stages of ovarian development induced the virtual disappearance of primordial follicles in the postnatal ovary, while half the follicular reserve remained present after irradiation during the zygotene/pachytene stages. This sensitivity difference was correlated with the level of caspase-2 expression evaluated by immunohistochemistry. At the… CONTINUE READING

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