Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria.

@article{Guo2002Caspase2IA,
  title={Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria.},
  author={Yin Guo and Srinivasa M. Srinivasula and A. M. Druilhe and Teresa Fernandes-Alnemri and Emad S. Alnemri},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 16},
  pages={
          13430-7
        }
}
Caspase-2 is one of the earliest identified caspases, but the mechanism of caspase-2-induced apoptosis remains unknown. We show here that caspase-2 engages the mitochondria-dependent apoptotic pathway by inducing the release of cytochrome c (Cyt c) and other mitochondrial apoptogenic factors into the cell cytoplasm. In support of these observations we found that Bcl-2 and Bcl-xL can block caspase-2- and CRADD (caspase and RIP adaptor with death domain)-induced cell death. Unlike caspase-8… CONTINUE READING
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