Caspase-2 cleaves DNA fragmentation factor (DFF45)/inhibitor of caspase-activated DNase (ICAD).

@article{Dahal2007Caspase2CD,
  title={Caspase-2 cleaves DNA fragmentation factor (DFF45)/inhibitor of caspase-activated DNase (ICAD).},
  author={Giri Raj Dahal and Pratap Karki and Arjun Thapa and Mohammad Shahnawaz and Song Yub Shin and Jung Sup Lee and Byungyun Cho and I Park},
  journal={Archives of biochemistry and biophysics},
  year={2007},
  volume={468 1},
  pages={134-9}
}
To investigate the signal transduction pathway of caspase-2, cell permeable Tat-reverse-caspase-2 was constructed, characterized and utilized for biochemical and cellular studies. It could induce the cell death as early as 2h, and caspase-2-specific VDVADase activity but not other caspase activities including DEVDase and IETDase. Interestingly, nuclear DNA fragmentation occurred and consistently DNA fragmentation factor (DFF45)/Inhibitor of caspase-activated DNase (ICAD) was cleaved inside the… CONTINUE READING