Caspase-2: controversial killer or checkpoint controller?

  title={Caspase-2: controversial killer or checkpoint controller?},
  author={Tanja Kitevska and Damian M. S. Spencer and Christine J Hawkins},
The caspases are an evolutionarily conserved family of cysteine proteases, with essential roles in apoptosis or inflammation. Caspase-2 was the second caspase to be cloned and it resembles the prototypical nematode caspase CED-3 more closely than any other mammalian protein. An absence of caspase-2-specific reagents and the subtle phenotype of caspase-2-deficient mice have hampered definition of the physiological role of caspase-2 and identification of factors regulating its activity. Although… CONTINUE READING


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