Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

  title={Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β},
  author={Toshiyuki Nakagawa and Hong Zhu and Nobuhiro Morishima and En Li and Jin Xu and Bruce A. Yankner and Junying Yuan},
Apoptosis, or cellular suicide, is important for normal development and tissue homeostasis, but too much or too little apoptosis can also cause disease. The family of cysteine proteases, the so-called caspases, are critical mediators of programmed cell death, and thus far 14 family members have been identified. Some of these, such as caspase-8 (refs 4, 5), mediate signal transduction downstream of death receptors located on the plasma membrane. Others, such as caspase-9 (ref. 6), mediate… CONTINUE READING
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