Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

@article{Nakagawa2000Caspase12ME,
  title={Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β},
  author={Toshiyuki Nakagawa and Hong Zhu and Nobuhiro Morishima and En Li and Jin Xu and Bruce A. Yankner and Junying Yuan},
  journal={Nature},
  year={2000},
  volume={403},
  pages={98-103}
}
Apoptosis, or cellular suicide, is important for normal development and tissue homeostasis, but too much or too little apoptosis can also cause disease. The family of cysteine proteases, the so-called caspases, are critical mediators of programmed cell death, and thus far 14 family members have been identified. Some of these, such as caspase-8 (refs 4, 5), mediate signal transduction downstream of death receptors located on the plasma membrane. Others, such as caspase-9 (ref. 6), mediate… CONTINUE READING
Highly Influential
This paper has highly influenced 78 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 1,210 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

Phospholipase Cg and phosphoinositide 3 - kinase mediate cytoplasmic signalling in nerve growth cone guidance

  • G. Ming
  • Neuron
  • 1999

Similar Papers

Loading similar papers…