Caspase-12 compensates for lack of caspase-2 and caspase-3 in female germ cells

  title={Caspase-12 compensates for lack of caspase-2 and caspase-3 in female germ cells},
  author={Yasushi Takai and Tiina Matikainen and Andrea Jurisicova and Mi Ran Kim and Alexander M. Trbovich and Eriko Fujita and Toshiyuki Nakagawa and B{\'e}n{\'e}dicte Lemmers and Richard A Flavell and Razqallah Hakem and Takashi Momoi and Jing Yuan and Jonathan L. Tilly and Gloria Ines Perez},
Previously, we analyzed mice lacking either caspase-2 or caspase-3 and documented a role for caspase-2 in developmental and chemotherapy-induced apoptosis of oocytes. Those data also revealed dispensability of caspase-3, although we found this caspase critical for ovarian granulosa cell death. Because of the mutual interdependence of germ cells and granulosa cells, herein we generated caspase-2 and -3 double-mutant (DKO) mice to evaluate how these two caspases functionally relate to each other… CONTINUE READING


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