Caspase-11 plays an essential role in methamphetamine-induced dopaminergic neuron apoptosis.

@article{Huang2015Caspase11PA,
  title={Caspase-11 plays an essential role in methamphetamine-induced dopaminergic neuron apoptosis.},
  author={Weiye Huang and Wei-bing Xie and Dongfang Qiao and Pingming Qiu and Enping Huang and Bing Li and Chuanxiang Chen and Chao Liu and Qi Yun Wang and Zhoumeng Lin and Haifeng Wang},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2015},
  volume={145 1},
  pages={
          68-79
        }
}
Methamphetamine (METH) is an extremely addictive stimulant drug that is widely used with high potential of abuse. Previous studies have shown that METH exposure damages the nervous system, especially dopaminergic neurons. However, the exact molecular mechanisms of METH-induced neurotoxicity remain unclear. We hypothesized that caspase-11 is involved in METH-induced neuronal apoptosis. We tested our hypothesis by examining the change of caspase-11 protein expression in dopaminergic neurons (PC12… CONTINUE READING

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