Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock.

@article{Yang2015Caspase11RT,
  title={Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock.},
  author={Dahai Yang and Yuan He and Ra{\'u}l Mu{\~n}oz-Planillo and Jingjing Liu and Gabriel N{\'u}{\~n}ez},
  journal={Immunity},
  year={2015},
  volume={43 5},
  pages={923-32}
}
The noncanonical inflammasome induced by intracellular lipopolysaccharide (LPS) leads to caspase-11-dependent pyroptosis, which is critical for induction of endotoxic shock in mice. However, the signaling pathway downstream of caspase-11 is unknown. We found that cytosolic LPS stimulation induced caspase-11-dependent cleavage of the pannexin-1 channel followed up by ATP release, which in turn activated the purinergic P2X7 receptor to mediate cytotoxicity. In the absence of P2X7 or pannexin-1… CONTINUE READING
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