Caspase-1 is active since the early phase of rheumatoid arthritis

  title={Caspase-1 is active since the early phase of rheumatoid arthritis},
  author={Rita Casc{\~a}o and Joaquim Polido-Pereira and Helena Canh{\~a}o and Ana Maria Rodrigues and M{\'a}rcio Navalho and Helena Raquel and A F Mour{\~a}o and Cristina do Amparo Resende and Jos{\'e} Fonseca and Luis Ferreira Moita},
  booktitle={Journal of Translational Medicine},
Introduction Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint destruction. We have previously reported an increase in interleukin (IL)-1b levels in the serum of very early RA and in the synovial fluid (SF) of RA patients. Therefore, the molecular mechanisms that regulate IL-1b activation, such as caspase-1, might play a relevant role and have potential as therapeutic targets in RA. 

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