Caspase-1 inhibitors abolish deleterious enhancement of COX-2 expression induced by HIV-1 gp120 in human neuroblastoma cells.

Abstract

The human CHP100 neuroblastoma cell line has been shown to provide an useful in vitro model to elucidate the mechanisms underlying HIV-1 gp120 neurotoxicity. Here we report western blotting evidence demonstrating that exposure to a cytotoxic concentration of the viral coat protein up-regulates expression of the inducible isoform of cyclooxygenase (COX-2) in… (More)

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@article{Corasaniti2003Caspase1IA, title={Caspase-1 inhibitors abolish deleterious enhancement of COX-2 expression induced by HIV-1 gp120 in human neuroblastoma cells.}, author={Maria Tiziana Corasaniti and Carlos Eduardo Bellizzi and Rossella Russo and Carmela Colica and Diana Amantea and Gianfranco F Di Renzo}, journal={Toxicology letters}, year={2003}, volume={139 2-3}, pages={213-9} }