Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function.

@article{Guey2014Caspase1AI,
  title={Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function.},
  author={Baptiste Guey and M{\'e}lanie Bodnar and Serge N. Mani{\'e} and Aubry Tardivel and Virginie P{\'e}trilli},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 48},
  pages={17254-9}
}
Inflammasomes are caspase-1-activating multiprotein complexes. The mouse nucleotide-binding domain and leucine rich repeat pyrin containing 1b (NLRP1b) inflammasome was identified as the sensor of Bacillus anthracis lethal toxin (LT) in mouse macrophages from sensitive strains such as BALB/c. Upon exposure to LT, the NLRP1b inflammasome activates caspase-1… CONTINUE READING