Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8.

Abstract

Canonical inflammasomes are multiprotein complexes that can activate both caspase-1 and caspase-8. Caspase-1 drives rapid lysis of cells by pyroptosis and maturation of interleukin (IL)-1β and IL-18. In caspase-1-deficient cells, inflammasome formation still leads to caspase-3 activation and slower apoptotic death, dependent on caspase-8 as an apical… (More)
DOI: 10.1016/j.jmb.2017.10.028

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Cite this paper

@article{Sagulenko2018Caspase1IA, title={Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8.}, author={Vitaliya Sagulenko and Nazarii Y Vitak and Parimala Rao Vajjhala and James Edward Vince and Katryn J. Stacey}, journal={Journal of molecular biology}, year={2018}, volume={430 2}, pages={238-247} }