Caspar-like gene depletion reduces Leishmania infection in sand fly host Lutzomyia longipalpis.

@article{Telleria2012CasparlikeGD,
  title={Caspar-like gene depletion reduces Leishmania infection in sand fly host Lutzomyia longipalpis.},
  author={Erich Loza Telleria and Maur{\'i}cio R. V. Sant'Anna and Jo{\~a}o Ramalho Ortig{\~a}o-Farias and Andr{\'e} N{\'o}brega Pitaluga and Viv Maureen Dillon and Paul A. Bates and Yara Maria Traub-Csek{\"o} and Rod Dillon},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 16},
  pages={12985-93}
}
Female phlebotomine sand flies Lutzomyia longipalpis naturally harbor populations of the medically important Leishmania infantum (syn. Leishmania chagasi) parasite in the gut, but the extent to which the parasite interacts with the immune system of the insect vector is unknown. To investigate the sand fly immune response and its interaction with the Leishmania parasite, we identified a homologue for caspar, a negative regulator of immune deficiency signaling pathway. We found that feeding… CONTINUE READING
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