Casitas B lineage lymphoma b is a key regulator of peripheral tolerance in systemic lupus erythematosus.

@article{GmezMartn2013CasitasBL,
  title={Casitas B lineage lymphoma b is a key regulator of peripheral tolerance in systemic lupus erythematosus.},
  author={Diana G{\'o}mez-Mart{\'i}n and Mar{\'i}a de Jes{\'u}s Ibarra-S{\'a}nchez and J Romo-Tena and Jos{\'e} Cruz-Ru{\'i}z and Jos{\'e} Esparza-L{\'o}pez and Miguel A. Galindo-Campos and Mariana D{\'i}az-Zamudio and Jorge Alcocer-Varela},
  journal={Arthritis and rheumatism},
  year={2013},
  volume={65 4},
  pages={1032-42}
}
OBJECTIVE To analyze whether the expression and modulation of T cell receptor (TCR) signaling is dependent on Casitas B lineage lymphoma b (Cbl-b) in T cells from patients with systemic lupus erythematosus (SLE) upon stimulation with a tolerogenic substance. METHODS Peripheral blood mononuclear cells were obtained from 20 patients with SLE (active disease or in remission) and 20 healthy controls. Levels of Cbl-b expression were measured using reverse transcription-polymerase chain reaction… CONTINUE READING