Casitas B-cell lymphoma (Cbl) proteins protect mammary epithelial cells from proteotoxicity of active c-Src accumulation.

@article{Mukhopadhyay2016CasitasBL,
  title={Casitas B-cell lymphoma (Cbl) proteins protect mammary epithelial cells from proteotoxicity of active c-Src accumulation.},
  author={Chandrani Mukhopadhyay and Aleata A. Triplett and Tom W. Bargar and Carol A. Heckman and K U Wagner and Mayumi Naramura},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 51},
  pages={E8228-E8237}
}
Casitas B-cell lymphoma (Cbl) family ubiquitin ligases negatively regulate tyrosine kinase-dependent signal transduction by promoting degradation of active kinases. We and others previously reported that loss of Cbl functions caused hyperproliferation in lymphoid and hematopoietic systems. Unexpectedly, Cbl deletion in Cbl-b-null, Cbl-c-null primary mouse mammary epithelial cells (MECs) (Cbl triple-deficiency) induced rapid cell death despite enhanced MAP kinase and AKT activation. Acute Cbl… CONTINUE READING
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