Casein kinase II phosphorylates lens connexin 45.6 and is involved in its degradation.

@article{Yin2000CaseinKI,
  title={Casein kinase II phosphorylates lens connexin 45.6 and is involved in its degradation.},
  author={Xinye Yin and Paul T Jedrzejewski and Jean X Jiang},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 10},
  pages={6850-6}
}
Connexin (Cx) 45.6, an avian counterpart of rodent Cx50, is phosphorylated in vivo, but the sites and function of the phosphorylation have not been elucidated. Our peptide mapping experiments showed that the Ser(363) site in the carboxyl (COOH) terminus of Cx45.6 was phosphorylated and that this site is within casein kinase (CK) II consensus sequence, although showing some similarity to CKI sequence. The peptide containing Ser(363) could be phosphorylated in vitro by CKII, but not by CKI… CONTINUE READING