Casein kinase II associates with Egr-1 and acts as a negative modulator of its DNA binding and transcription activities in NIH 3T3 cells.

@article{Jain1996CaseinKI,
  title={Casein kinase II associates with Egr-1 and acts as a negative modulator of its DNA binding and transcription activities in NIH 3T3 cells.},
  author={Nidhi Jain and Ratha Mahendran and Roger Philp and Graeme R. Guy and Yves S H Tan and X M Cao},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 23},
  pages={13530-6}
}
Although the activation domains within early growth response gene protein 1 (Egr-1) have been mapped, little is known of the kinases which phosphorylate Egr-1 and how phosphorylation correlates with the transcriptional activity of Egr-1. In this study we report that casein kinase II (CKII) co-immunoprecipitates with Egr-1 from NIH 3T3 cell lysates. The association of Egr-1 and CKII requires the C terminus of Egr-1 and CKII phosphorylates Egr-1 in vitro. The in vitro phosphorylation of Egr-1 by… CONTINUE READING
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