Casein kinase I is anchored on axonemal doublet microtubules and regulates flagellar dynein phosphorylation and activity.

@article{Yang2000CaseinKI,
  title={Casein kinase I is anchored on axonemal doublet microtubules and regulates flagellar dynein phosphorylation and activity.},
  author={Pinfen Yang and Winfield S Sale},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 25},
  pages={18905-12}
}
Flagellar dynein activity is regulated by phosphorylation. One critical phosphoprotein substrate in Chlamydomonas is the 138-kDa intermediate chain (IC138) of the inner arm dyneins (Habermacher, G., and Sale, W. S. (1997) J. Cell Biol. 136, 167-176). In this study, several approaches were used to determine that casein kinase I (CKI) is physically anchored in the flagellar axoneme and regulates IC138 phosphorylation and dynein activity. First, using a videomicroscopic motility assay, selective… CONTINUE READING

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