Casein kinase 2 inhibition decreases hypoxia-inducible factor-1 activity under hypoxia through elevated p53 protein level.

@article{Hubert2006CaseinK2,
  title={Casein kinase 2 inhibition decreases hypoxia-inducible factor-1 activity under hypoxia through elevated p53 protein level.},
  author={Antoine Hubert and S{\'e}bastien Paris and J P Piret and No{\"e}lle Ninane and Martine Raes and Carine Michiels},
  journal={Journal of cell science},
  year={2006},
  volume={119 Pt 16},
  pages={3351-62}
}
HIF-1 (hypoxia-inducible factor-1) is the main transcription factor involved in the adaptation of cells to hypoxia. In addition to regulation of HIF-1alpha protein level, HIF-1 activity is also enhanced by several pathways involving asparagine hydroxylation and phosphorylation. Here, we investigated the relationship between casein kinase 2 (CK2), p53 and HIF-1. An increase in p53 protein level and transcriptional activity was observed when CK2 was inhibited by different inhibitors under… CONTINUE READING

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