Casein kinase 1 isoform 2 is essential for bloodstream form Trypanosoma brucei☆

@inproceedings{Urbaniak2009CaseinK1,
  title={Casein kinase 1 isoform 2 is essential for bloodstream form Trypanosoma brucei☆},
  author={Michael D. Urbaniak},
  booktitle={Molecular and biochemical parasitology},
  year={2009}
}
Induction of RNA interference targeted against casein kinase 1 isoform 2 (TbCK1.2, Tb927.5.800) in bloodstream form Trypanosoma brucei in vitro results in rapid cessation of growth, gross morphological changes, multinucleation and ultimately cell death. A null mutant of the highly homologous casein kinase 1 isoform 1 (Tb927.5.790) in bloodstream form T. brucei displays no growth or morphological phenotype in vitro. A truncated form of TbCK1.2 expressed in Escherichia coli as a GST fusion… CONTINUE READING

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